BPC-157 Research Compound
Research Use Only
This product is intended for laboratory research purposes only. It is not intended for human or veterinary use, food, cosmetic, household, or agricultural applications. Not for human consumption.
Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids derived from human gastric juice. First characterized in the early 1990s, BPC-157 has become one of the most extensively studied peptides in regenerative research, with documented effects in tissue repair, angiogenesis, and gastrointestinal protection models.
Molecular Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C62H98N16O22 |
| Molecular Weight | 1419.53 g/mol |
| CAS Number | 137525-51-0 |
| Amino Acids | 15 |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Isoelectric Point | ~4.2 |
| Purity | ≥99% (HPLC) |
Mechanism of Action
Research indicates BPC-157 interacts with multiple biological pathways:
Nitric Oxide System
- Modulation of eNOS expression
- Interaction with NO-cGMP pathway
- Effects on vascular relaxation responses
Angiogenesis Pathways
- Upregulation of VEGF expression
- Enhanced endothelial cell migration
- VEGFR2 activation in cell culture studies
Growth Factor Interactions
- Enhanced EGF receptor expression
- FGF signaling modulation
- TGF-β pathway interactions
FAK-Paxillin Pathway
- Promotion of FAK phosphorylation
- Cell adhesion and migration effects
- Tissue organization mechanisms
Research Applications
Gastrointestinal Studies
- Mucosal protection mechanisms
- Inflammatory bowel research
- Gut barrier function
Musculoskeletal Research
- Tendon and ligament repair models
- Muscle injury studies
- Bone healing research
Vascular Research
- Angiogenesis mechanisms
- Wound healing models
- Vascular protection studies
Neurological Research
- Peripheral nerve regeneration
- Neuroprotective mechanisms
- Dopaminergic system interactions
Available Formats
| Size | Salt Form | Catalog Code |
|---|---|---|
| 5mg | Acetate | BPC-5A |
| 10mg | Acetate | BPC-10A |
| 5mg | Arginine | BPC-5R |
| 10mg | Arginine | BPC-10R |
| 15mg | Acetate | BPC-15A |
| 30mg | Acetate | BPC-30A |
Handling & Storage
- Store lyophilized peptide at -20°C
- Stable at -20°C for 2+ years
- Reconstitute with bacteriostatic water
- Reconstituted solution stable at 2-8°C for up to 4 weeks
- Resistant to gastric acid degradation
- Stable across pH range 3-8
Quality Specifications
- Purity: ≥99% by HPLC
- Appearance: White lyophilized powder
- Solubility: Freely soluble in water
- Endotoxin: Less than 1 EU/mg
- Heavy Metals: Less than 10 ppm
- Certificate of Analysis provided
References
- Sikiric P, et al. "Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract." Curr Pharm Des. 2011.
- Chang CH, et al. "The promoting effect of pentadecapeptide BPC 157 on tendon healing." J Appl Physiol. 2011.
- Hsieh MJ, et al. "Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation." J Mol Med. 2017.