CJC-1295 (no DAC) Research Compound
Research Use Only
This product is intended for laboratory research purposes only. It is not intended for human or veterinary use, food, cosmetic, household, or agricultural applications. Not for human consumption.
Overview
CJC-1295 (also known as Modified GRF 1-29 or Mod GRF) is a synthetic analog of growth hormone-releasing hormone (GHRH 1-29). The peptide has been modified at positions 2, 8, 15, and 27 to enhance stability against enzymatic degradation while maintaining full biological activity. The "no DAC" version lacks the Drug Affinity Complex, providing a shorter duration of action suitable for pulsatile GH research protocols.
Molecular Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C152H252N44O42 |
| Molecular Weight | 3367.97 g/mol |
| CAS Number | 863288-34-0 |
| Amino Acids | 29 |
| Modifications | D-Ala2, Gln8, Ala15, Leu27 |
| Purity | ≥99% (HPLC) |
| Storage | -20°C, protected from light |
Mechanism of Action
CJC-1295 stimulates growth hormone release through GHRH receptor activation:
Pituitary Activation
- Binding to GHRH receptors on somatotrophs
- Cyclic AMP pathway activation
- GH synthesis and secretion
- Pulsatile release pattern preservation
Enhanced Stability
- Resistance to DPP-IV degradation
- Extended half-life vs. native GHRH
- Maintained receptor specificity
- Preserved biological activity
Synergistic Potential
- Complementary action with GHRPs
- Enhanced GH pulse amplitude
- Maintained negative feedback
- IGF-1 axis stimulation
Research Applications
Growth Hormone Studies
- GH pulsatility research
- Somatotroph function assessment
- Age-related GH decline
- GH replacement models
Body Composition Research
- Lean mass studies
- Fat oxidation research
- Metabolic rate assessment
- Recovery protocols
Combined Peptide Research
- GHRH + GHRP synergy studies
- Dose optimization research
- Timing protocol development
- Comparative efficacy analysis
Pharmacokinetic Studies
- Half-life determination
- Bioavailability assessment
- Receptor binding studies
- Metabolic pathway analysis
Available Formats
| Size | Format | Catalog Code |
|---|---|---|
| 2mg | Lyophilized | CJC-2 |
| 5mg | Lyophilized | CJC-5 |
| 10mg | Lyophilized | CJC-10 |
Handling & Storage
- Store lyophilized peptide at -20°C
- Protect from light and moisture
- Reconstitute with bacteriostatic water
- Reconstituted solution stable at 2-8°C for up to 4 weeks
- Avoid repeated freeze-thaw cycles
- Use within 30 minutes of warming to room temperature
Quality Specifications
- Purity: ≥99% by HPLC
- Appearance: White lyophilized powder
- Solubility: Soluble in water
- Endotoxin: Less than 1 EU/mg
- Certificate of Analysis provided
CJC-1295 Versions Comparison
| Version | DAC | Half-Life | Dosing Pattern |
|---|---|---|---|
| CJC-1295 (no DAC) | No | ~30 min | Multiple daily |
| CJC-1295 DAC | Yes | ~8 days | Weekly |
References
- Teichman SL, et al. "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295." J Clin Endocrinol Metab. 2006.
- Alba M, et al. "Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth." J Clin Endocrinol Metab. 2006.
- Ionescu M, et al. "Pulsatile secretion of growth hormone (GH) persists during continuous stimulation." Endocrinology. 2004.