GHK-Cu Research Compound
Research Use Only
This product is intended for laboratory research purposes only. It is not intended for human or veterinary use, food, cosmetic, household, or agricultural applications. Not for human consumption.
Overview
GHK-Cu (Glycyl-L-Histidyl-L-Lysine:Copper) is a naturally occurring tripeptide with a high affinity for copper(II) ions. First identified in human plasma in 1973, GHK-Cu has been extensively studied for its role in wound healing, collagen synthesis, and tissue remodeling. Research has documented its ability to upregulate collagen production by up to 70% in certain experimental models.
Molecular Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C14H24CuN6O4 |
| Molecular Weight | 403.93 g/mol |
| CAS Number | 49557-75-7 |
| Sequence | Gly-His-Lys:Cu(II) |
| Copper Content | ~15.7% |
| Purity | ≥98% (HPLC) |
| Appearance | Blue powder (due to copper) |
Mechanism of Action
GHK-Cu exerts biological effects through multiple pathways:
Collagen & ECM Remodeling
- Stimulation of collagen I, III synthesis
- Increased elastin production
- Glycosaminoglycan synthesis enhancement
- MMP regulation for ECM turnover
Growth Factor Modulation
- VEGF upregulation for angiogenesis
- NGF (nerve growth factor) stimulation
- TGF-β pathway interactions
- FGF modulation
Antioxidant & Anti-Inflammatory
- SOD (superoxide dismutase) enzyme activity
- Reduction of inflammatory cytokines (IL-6, TNF-α)
- Iron chelation (Fenton reaction prevention)
Gene Expression
- Modulation of 4,000+ genes
- Activation of tissue remodeling genes
- Suppression of inflammation-related genes
Research Applications
Skin Biology Research
- Collagen synthesis studies
- Photoaging models
- Dermal thickness assessment
- Fibroblast activation
Wound Healing Studies
- Acute wound closure models
- Chronic wound research
- Scar formation studies
- Angiogenesis quantification
Hair Follicle Research
- Follicle size and density
- Hair cycle regulation
- Dermal papilla cell studies
Tissue Engineering
- Scaffold integration studies
- Cell migration assays
- ECM deposition research
Available Formats
| Size | Format | Catalog Code |
|---|---|---|
| 50mg | Lyophilized | GHK-50 |
| 100mg | Lyophilized | GHK-100 |
| 200mg | Lyophilized | GHK-200 |
| 100mg | Solution (1%) | GHK-SOL |
Handling & Storage
- Store lyophilized powder at -20°C
- Protect from light (copper complex is light-sensitive)
- Reconstitute with sterile water or appropriate buffer
- Solution stable at 2-8°C for up to 2 weeks
- Blue color indicates active copper complex
- Avoid contact with reducing agents
Quality Specifications
- Purity: ≥98% by HPLC
- Appearance: Blue lyophilized powder
- Copper Content: 15-16%
- Solubility: Soluble in water
- Endotoxin: Less than 1 EU/mg
- Certificate of Analysis provided
Note on Regulatory Status
As of 2024, GHK-Cu was included in FDA's list of compounds not suitable for compounding. This designation applies to compounded medications, not research use.
References
- Pickart L, et al. "The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions." Oxid Med Cell Longev. 2012.
- Pickart L, Margolina A. "Regenerative and protective actions of GHK-Cu peptide." Int J Mol Sci. 2018.
- Siméon A, et al. "Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex." J Invest Dermatol. 2000.