NAD+ Research Compound
Research Use Only
This product is intended for laboratory research purposes only. It is not intended for human or veterinary use, food, cosmetic, household, or agricultural applications. Not for human consumption.
Overview
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in all living cells. It plays a critical role in cellular energy metabolism, serving as a key electron carrier in the mitochondrial electron transport chain. Beyond energy production, NAD+ is a required substrate for sirtuins, PARPs, and CD38, enzymes involved in DNA repair, gene expression, and cellular signaling. NAD+ levels decline with age, making it a focus of longevity research.
Molecular Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C21H27N7O14P2 |
| Molecular Weight | 663.43 g/mol |
| CAS Number | 53-84-9 |
| Form | Oxidized (NAD+) |
| Purity | ≥99% (Enzymatic) |
| Storage | -20°C, desiccated |
Mechanism of Action
NAD+ is central to multiple cellular processes:
Energy Metabolism
- Electron carrier in glycolysis
- Critical for TCA cycle function
- Essential for oxidative phosphorylation
- ATP production regulation
Sirtuin Activation
- SIRT1-7 enzymatic substrate
- Deacetylation reactions
- Gene silencing (heterochromatin)
- Metabolic regulation
DNA Repair
- PARP1/2 substrate for DNA repair
- Base excision repair pathway
- Double-strand break repair
- Genomic stability maintenance
Cellular Signaling
- CD38/CD157 signaling
- Calcium signaling via cADPR
- Immune cell function
- Inflammation modulation
Research Applications
Aging & Longevity
- NAD+ decline with age studies
- Intervention timing research
- Healthspan biomarker assessment
- Comparative species analysis
Metabolic Research
- Mitochondrial function studies
- Energy metabolism assessment
- Metabolic syndrome models
- Obesity research
Sirtuin Biology
- SIRT1 activation studies
- Caloric restriction mimetics
- Epigenetic regulation
- Circadian rhythm research
Neurological Research
- Neurodegeneration models
- Axonal protection studies
- Cognitive function assessment
- Brain energy metabolism
Available Formats
| Size | Format | Catalog Code |
|---|---|---|
| 100mg | Lyophilized | NAD-100 |
| 250mg | Lyophilized | NAD-250 |
| 500mg | Lyophilized | NAD-500 |
| 1g | Lyophilized | NAD-1000 |
Handling & Storage
- Store lyophilized NAD+ at -20°C
- Keep desiccated (moisture-sensitive)
- Protect from light
- Reconstitute with cold sterile water
- Use immediately after reconstitution
- Avoid repeated freeze-thaw cycles
- Monitor for yellow discoloration (degradation)
Quality Specifications
- Purity: ≥99% by HPLC
- Appearance: White to off-white powder
- Solubility: Soluble in water
- Activity: Verified enzymatic activity
- Endotoxin: Less than 1 EU/mg
- Certificate of Analysis provided
NAD+ vs. Precursors
| Compound | Route | Conversion Required |
|---|---|---|
| NAD+ | Direct | None |
| NMN | Oral | One step (NMNAT) |
| NR | Oral | Two steps (NRK + NMNAT) |
| Niacin | Oral | Multiple steps |
References
- Verdin E. "NAD+ in aging, metabolism, and neurodegeneration." Science. 2015.
- Rajman L, et al. "Therapeutic potential of NAD-boosting molecules." Cell Metab. 2018.
- Yoshino J, et al. "NAD+ intermediates: The biology and therapeutic potential." Cell Metab. 2018.