Selank Research Compound
Research Use Only
This product is intended for laboratory research purposes only. It is not intended for human or veterinary use, food, cosmetic, household, or agricultural applications. Not for human consumption.
Overview
Selank is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is based on the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg), which is part of the IgG molecule, with an additional Pro-Gly-Pro C-terminal sequence for enhanced stability. Selank has been registered in Russia as a medication and is studied for its anxiolytic, nootropic, and immunomodulatory properties.
Molecular Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C33H57N11O9 |
| Molecular Weight | 751.88 g/mol |
| CAS Number | 129954-34-3 |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Derived From | Tuftsin + Pro-Gly-Pro |
| Purity | ≥99% (HPLC) |
| Storage | -20°C, protected from light |
Mechanism of Action
Selank modulates multiple neurobiological systems:
GABAergic System
- Allosteric modulation of GABA-A receptors
- Enhanced GABAergic neurotransmission
- Benzodiazepine-like effects without dependence
- GABA transaminase interactions
Monoamine Systems
- Serotonin metabolism modulation
- Dopamine pathway interactions
- Norepinephrine system effects
- MAO activity modulation
Neurotrophic Effects
- BDNF expression enhancement
- NGF modulation
- Neuroplasticity promotion
- Synaptic function support
Immune Modulation
- Tuftsin-like immunostimulatory effects
- Cytokine profile modulation
- NK cell activity enhancement
- Phagocytosis stimulation
Research Applications
Anxiety & Stress Research
- Elevated plus maze studies
- Open field test models
- Chronic stress paradigms
- Fear conditioning research
GABA System Studies
- Receptor binding assays
- Electrophysiology studies
- Neurotransmitter release measurements
- Anxiolytic mechanism research
Cognitive Function
- Memory consolidation studies
- Learning enhancement models
- Attention paradigms
- Nootropic stacking research
Immunology Research
- Immune cell activation studies
- Cytokine profiling
- Stress-immune interactions
- Psychoneuroimmunology
Available Formats
| Size | Format | Catalog Code |
|---|---|---|
| 5mg | Lyophilized | SEL-5 |
| 10mg | Lyophilized | SEL-10 |
| 30mg | Lyophilized | SEL-30 |
Handling & Storage
- Store lyophilized peptide at -20°C
- Protect from light and moisture
- Reconstitute with bacteriostatic water
- Reconstituted solution stable at 2-8°C for up to 4 weeks
- Compatible with intranasal delivery systems
- Stable in physiological pH range
Quality Specifications
- Purity: ≥99% by HPLC
- Appearance: White lyophilized powder
- Solubility: Freely soluble in water
- Endotoxin: Less than 1 EU/mg
- Certificate of Analysis provided
Regulatory Notes
Selank was registered in Russia in 2009 for anxiety and neurasthenia. In September 2024, it was removed from FDA Category 2 list, potentially opening pathways for further research in the US.
Comparison with Semax
| Property | Selank | Semax |
|---|---|---|
| Primary Effect | Anxiolytic | Nootropic |
| Derived From | Tuftsin | ACTH (4-10) |
| GABA Effects | Strong | Moderate |
| BDNF Effects | Moderate | Strong |
| Immune Effects | Significant | Minimal |
References
- Seredenin SB, et al. "Anxiolytic action of Selank peptide." Bull Exp Biol Med. 1998.
- Kozlovskii II, et al. "The role of the GABAergic system in the anxiolytic effect of Selank." Neurosci Behav Physiol. 2003.
- Kost NV, et al. "Semax and Selank inhibit the enkephalin-degrading enzymes from human serum." Bioorg Khim. 2001.