Semaglutide Research Compound
Research Use Only
This product is intended for laboratory research purposes only. It is not intended for human or veterinary use, food, cosmetic, household, or agricultural applications. Not for human consumption.
Overview
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1) developed for metabolic research applications. As a GLP-1 receptor agonist, it mimics the incretin hormone GLP-1, which plays a crucial role in glucose-dependent insulin secretion and appetite regulation.
Molecular Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.58 g/mol |
| CAS Number | 910463-68-2 |
| Purity | ≥99% (HPLC) |
| Storage | -20°C, protected from light |
Mechanism of Action
Semaglutide activates GLP-1 receptors, leading to:
- Glucose-dependent insulin secretion - Enhanced insulin release in response to elevated glucose
- Glucagon suppression - Reduced hepatic glucose output
- Delayed gastric emptying - Slowed nutrient absorption
- Central appetite regulation - Effects on hypothalamic satiety centers
The peptide features a fatty acid side chain (C18 diacid) attached to lysine at position 26, enabling non-covalent albumin binding and extending the half-life to approximately 7 days.
Research Applications
Metabolic Studies
- Glucose homeostasis mechanisms
- Insulin sensitivity research
- Beta-cell function studies
Appetite & Satiety Research
- Central nervous system GLP-1 receptor signaling
- Food intake regulation
- Reward pathway interactions
Cardiovascular Research
- Cardiac GLP-1 receptor expression
- Vascular endothelial function
- Lipid metabolism
Available Formats
| Size | Format | Catalog Code |
|---|---|---|
| 5mg | Lyophilized | SEM-5 |
| 10mg | Lyophilized | SEM-10 |
| 15mg | Lyophilized | SEM-15 |
| 30mg | Lyophilized | SEM-30 |
Handling & Storage
- Store lyophilized peptide at -20°C
- Protect from light and moisture
- Reconstitute with bacteriostatic water or sterile water
- Reconstituted solution stable at 2-8°C for up to 4 weeks
- Avoid freeze-thaw cycles
Quality Specifications
- Purity: ≥99% by HPLC
- Appearance: White to off-white lyophilized powder
- Solubility: Soluble in sterile water
- Endotoxin: Less than 1 EU/mg
- Certificate of Analysis provided with each batch
References
- Marso SP, et al. "Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes." N Engl J Med. 2016.
- Wilding JPH, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." N Engl J Med. 2021.
- Knudsen LB, Lau J. "The Discovery and Development of Liraglutide and Semaglutide." Front Endocrinol. 2019.