TB-500 Research Compound
Research Use Only
This product is intended for laboratory research purposes only. It is not intended for human or veterinary use, food, cosmetic, household, or agricultural applications. Not for human consumption.
Overview
TB-500 is a synthetic version of thymosin beta-4, a 43-amino acid protein that is naturally present in nearly all human and animal cells. Thymosin beta-4 is a key regulator of actin, a protein critical for cell structure, movement, and tissue organization. TB-500 research focuses on its role in cell migration, angiogenesis, and tissue repair processes.
Molecular Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C212H350N56O78S |
| Molecular Weight | 4963.44 g/mol |
| CAS Number | 77591-33-4 |
| Amino Acids | 43 |
| Active Region | LKKTETQ (17-23) |
| Purity | ≥99% (HPLC) |
| Storage | -20°C, protected from light |
Mechanism of Action
TB-500 exerts its effects through several key mechanisms:
Actin Regulation
- Binds G-actin monomers
- Promotes actin polymerization
- Regulates cytoskeletal dynamics
Cell Migration
- Upregulation of cell migration markers
- Enhanced lamellipodium formation
- Promotes wound edge cell motility
Angiogenesis
- Stimulates endothelial cell migration
- Promotes capillary tube formation
- VEGF pathway interactions
Anti-Inflammatory Effects
- Modulation of inflammatory cytokines
- NF-κB pathway interactions
- Macrophage phenotype regulation
Research Applications
Wound Healing Studies
- Dermal wound closure models
- Corneal repair research
- Mucosal healing studies
Cardiac Research
- Myocardial repair mechanisms
- Post-infarction remodeling
- Cardiac progenitor cell activation
Musculoskeletal Research
- Muscle strain recovery models
- Tendon repair studies
- Ligament healing research
Neurological Research
- Neural stem cell migration
- Oligodendrocyte development
- CNS repair mechanisms
Available Formats
| Size | Format | Catalog Code |
|---|---|---|
| 2mg | Lyophilized | TB-2 |
| 5mg | Lyophilized | TB-5 |
| 10mg | Lyophilized | TB-10 |
Handling & Storage
- Store lyophilized peptide at -20°C
- Protect from light and moisture
- Reconstitute with bacteriostatic water
- Reconstituted solution stable at 2-8°C for up to 3 weeks
- Avoid repeated freeze-thaw cycles
- Use sterile technique during handling
Quality Specifications
- Purity: ≥99% by HPLC
- Appearance: White to off-white lyophilized powder
- Solubility: Soluble in sterile water
- Endotoxin: Less than 1 EU/mg
- Certificate of Analysis provided
Synergistic Research
TB-500 is commonly studied in combination with BPC-157 (the "Wolverine Stack") due to complementary mechanisms:
- BPC-157: Angiogenesis and growth factor pathways
- TB-500: Actin regulation and cell migration
References
- Goldstein AL, et al. "Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues." Trends Mol Med. 2005.
- Bock-Marquette I, et al. "Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration." Nature. 2004.
- Smart N, et al. "Thymosin beta-4 is essential for coronary vessel development." Dev Biol. 2007.