Tirzepatide Research Compound
Research Use Only
This product is intended for laboratory research purposes only. It is not intended for human or veterinary use, food, cosmetic, household, or agricultural applications. Not for human consumption.
Overview
Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. This novel peptide represents a significant advancement in incretin-based research, combining the effects of two key metabolic hormones in a single molecule.
Molecular Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C225H348N48O68 |
| Molecular Weight | 4813.45 g/mol |
| CAS Number | 2023788-19-2 |
| Amino Acids | 39 |
| Purity | ≥99% (HPLC) |
| Storage | -20°C, protected from light |
Mechanism of Action
Tirzepatide acts as a dual agonist with:
GIP Receptor Activation
- Enhanced first-phase insulin secretion
- Improved beta-cell function
- Potential adipose tissue effects
GLP-1 Receptor Activation
- Glucose-dependent insulin release
- Glucagon suppression
- Delayed gastric emptying
- Central appetite regulation
The synergistic activation of both receptors produces enhanced metabolic effects compared to single-receptor agonists.
Research Applications
Dual Incretin Signaling Studies
- Comparative efficacy vs. single agonists
- Receptor interaction dynamics
- Signal transduction pathways
Metabolic Research
- Glucose homeostasis mechanisms
- Insulin sensitivity enhancement
- Beta-cell preservation studies
Body Composition Research
- Adipose tissue metabolism
- Lean mass preservation
- Energy expenditure modulation
Available Formats
| Size | Format | Catalog Code |
|---|---|---|
| 5mg | Lyophilized | TIR-5 |
| 10mg | Lyophilized | TIR-10 |
| 15mg | Lyophilized | TIR-15 |
| 30mg | Lyophilized | TIR-30 |
Handling & Storage
- Store lyophilized peptide at -20°C
- Protect from light and moisture
- Reconstitute with bacteriostatic water
- Reconstituted solution stable at 2-8°C for up to 4 weeks
- Avoid repeated freeze-thaw cycles
Quality Specifications
- Purity: ≥99% by HPLC
- Appearance: White lyophilized powder
- Solubility: Soluble in sterile water
- Endotoxin: Less than 1 EU/mg
- Certificate of Analysis provided
References
- Frias JP, et al. "Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes." N Engl J Med. 2021.
- Jastreboff AM, et al. "Tirzepatide Once Weekly for the Treatment of Obesity." N Engl J Med. 2022.
- Nauck MA, et al. "GIP and GLP-1: Potent Metabolic Hormones." Diabetes. 2020.